Description

1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)-2,2,2-Trifluoroethanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the trifluoroacetyl group adjacent to the benzodioxane scaffold, enabling the construction of complex molecules with enhanced physicochemical properties. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the benzodioxane moiety's prevalence in bioactive molecules.
• Agrochemical Research: Serves as a precursor in the development of new herbicides, fungicides, and insecticides, where the introduction of fluorine atoms can improve metabolic stability and bioavailability.
• Material Science: Used in the research and development of specialty polymers, liquid crystals, and organic electronic materials where fluorinated aromatic units are required to modify electronic properties and stability.
• Chemical Synthesis: Acts as a versatile electrophile in Friedel-Crafts acylation reactions and as a precursor for heterocyclic compounds like imidazoles and pyrazoles via reactions with binucleophiles.
• Fluorine Chemistry: An important building block for introducing the trifluoromethyl ketone functional group, a valuable bioisostere in medicinal chemistry that can influence potency and pharmacokinetics.

Basic Information

Product Name	1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)-2,2,2-Trifluoroethanone
CAS No.	122243-34-9
Molecular Formula	C10H7F3O3
Molecular Weight	232.16 g/mol
Synonyms	6-(Trifluoroacetyl)-1,4-benzodioxane; 2,2,2-Trifluoro-1-(2,3-dihydro-1,4-benzodioxin-6-yl)ethanone; 1,4-Benzodioxin-6-yl trifluoromethyl ketone; 6-Trifluoroacetyl-2,3-dihydro-1,4-benzodioxine; 2,3-Dihydro-1,4-benzodioxin-6-yl trifluoromethyl ketone; 6-(2,2,2-Trifluoroacetyl)-2,3-dihydro-1,4-benzodioxine
EINECS	Contact for details

Quality Control

Our 1-(2,3-Dihydrobenzo[B][1,4]Dioxin-6-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.