Description

n-(4-Nitrophenyl)-L-Proline is a specialized chiral proline derivative featuring a nitrophenyl substituent, which serves as a key intermediate in advanced organic synthesis. This compound is valued for its role in constructing complex molecular architectures, particularly in pharmaceutical research and asymmetric catalysis. It is essential for chemists and researchers in the pharmaceutical, agrochemical, and fine chemical industries who require high-purity, structurally defined building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting protease inhibition or requiring proline-based scaffolds.
• Asymmetric Catalyst Ligand: Used in the development and synthesis of novel organocatalysts or metal-complex ligands for enantioselective transformations.
• Peptidomimetic Research: Serves as a constrained amino acid analog in the design and synthesis of peptide mimics for biochemical and medicinal chemistry studies.
• Agrochemical Synthesis: An intermediate in the production of advanced, chiral agrochemicals where specific stereochemistry is crucial for biological activity.
• Chemical Biology Probe: Utilized in the synthesis of molecular probes to study enzyme mechanisms or protein-protein interactions.
• Fine Chemical Production: Employed in custom synthesis and contract manufacturing for high-value, low-volume specialty chemicals.

Basic Information

Product Name	n-(4-Nitrophenyl)-L-Proline
CAS No.	122092-18-6
Molecular Formula	C₁₁H₁₂N₂O₄
Molecular Weight	236.23 g/mol
Synonyms	L-Proline, N-(4-nitrophenyl)-; (S)-1-(4-Nitrophenyl)pyrrolidine-2-carboxylic acid; N-(p-Nitrophenyl)-L-proline; 4-Nitro-N-[(2S)-pyrrolidin-2-ylmethyl]aniline (related form); 122092-18-6; N-(4-Nitrophenyl)proline; (S)-N-(4-Nitrophenyl)proline
EINECS	Contact for details

Quality Control

Our n-(4-Nitrophenyl)-L-Proline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing specific results for identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.