Description

2'-Fluoro-4'-(trifluoromethyl)acetophenone is a high-value fluorinated aromatic ketone building block essential for advanced organic synthesis. This compound matters for its unique trifluoromethyl and fluoro substituents, which impart desirable properties like enhanced metabolic stability and lipophilicity to final molecules. It is critically needed by pharmaceutical, agrochemical, and advanced material research and development teams for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) and inflammatory diseases.
• Agrochemical Synthesis: Used in developing new-generation herbicides, fungicides, and insecticides where the fluorine atoms improve biological activity and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated components in electronic display and lighting technologies.
• Organic Light-Emitting Diode (OLED) Intermediates: Employed in the synthesis of electron-transport or host materials for efficient OLED devices.
• Advanced Polymer Modification: Acts as a monomer or modifier to introduce fluorine into polymer chains, enhancing chemical resistance and thermal stability.
• Cross-Coupling Reactions: A valuable substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.

Basic Information

Product Name	2'-Fluoro-4'-(Trifluoromethyl)Acetophenone
CAS No.	122023-29-4
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1-(2-Fluoro-4-(trifluoromethyl)phenyl)ethan-1-one; 2'-Fluoro-4'-trifluoromethylacetophenone; 2-Fluoro-α,α,α-trifluoro-p-methylacetophenone; 1-Acetyl-2-fluoro-4-(trifluoromethyl)benzene; 2-Fluoro-4-trifluoromethylacetophenone; α,α,α,2-Tetrafluoro-4-methylacetophenone; p-(Trifluoromethyl)-o-fluoroacetophenone
EINECS	Contact for details

Quality Control

Our 2'-Fluoro-4'-(trifluoromethyl)acetophenone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. The container should be kept tightly sealed to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.