Description

2-Methyl-(3,6-Di-o-Acetyl-1,2,4-Trideoxy-4-Fluoroglucopyrano)-(2,1-D)-2-Oxazoline is a sophisticated fluorinated carbohydrate derivative and a key chiral building block in advanced organic synthesis. This compound matters for its role as a crucial intermediate in the development of novel pharmaceuticals, particularly nucleoside analogs and antiviral agents. Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity intermediate to enable the synthesis of complex, biologically active molecules with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel antiviral and anticancer nucleoside analogs.
• Glycochemistry Research: Used in the study and development of modified sugars and glycomimetics with enhanced metabolic stability.
• Probe & Diagnostic Development: Serves as a precursor for 18F-labeled PET (Positron Emission Tomography) tracers in medical imaging.
• Medicinal Chemistry: Enables structure-activity relationship (SAR) studies by introducing fluorine atoms into carbohydrate scaffolds to modulate drug properties.
• Process Chemistry: Employed in the scale-up and optimization of routes to fluorinated active pharmaceutical ingredients (APIs).
• Academic & Industrial R&D: A valuable reagent for exploring new reactions in fluoroorganic chemistry and carbohydrate chemistry.

Basic Information

Product Name	2-Methyl-(3,6-Di-o-Acetyl-1,2,4-Trideoxy-4-Fluoroglucopyrano)-(2,1-D)-2-Oxazoline
CAS No.	121496-67-1
Molecular Formula	C13H18FNO6
Molecular Weight	303.29 g/mol
Synonyms	4-Flu-oro-2,3,6-tri-O-acetyl-1,2,4-trideoxy-1-C-methyl-D-glucopyrano[2,1-d]-2-oxazoline; 1,2,4-Trideoxy-4-fluoro-1-C-methyl-2,3,6-tri-O-acetyl-α-D-glucopyrano[2,1-d]-2-oxazoline; 4-Fluoro-2,3,6-tri-O-acetyl-1,2,4-trideoxy-1-C-methyl-D-glucopyrano[2,1-d]-2-oxazoline; Fluorinated glucopyranosyl oxazoline; 1-C-Methyl-4-fluoro-2,3,6-tri-O-acetyl-1,2,4-trideoxy-α-D-glucopyrano[2,1-d]-2-oxazoline; CAS 121496-67-1
EINECS	Contact for details

Quality Control

Our 2-Methyl-(3,6-Di-o-Acetyl-1,2,4-Trideoxy-4-Fluoroglucopyrano)-(2,1-D)-2-Oxazoline is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.