Description

Desfuroyl Ceftiofur is a key active metabolite and synthetic intermediate of the third-generation cephalosporin antibiotic, ceftiofur. This compound is of significant importance in the pharmaceutical industry for the research, development, and quality control of veterinary and human antibacterial agents. It is primarily required by manufacturers of active pharmaceutical ingredients (APIs), analytical laboratories, and research institutions focused on antimicrobial efficacy and metabolite studies.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantitative and qualitative analysis of ceftiofur and its metabolites in biological samples and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a critical synthetic building block in the production of ceftiofur and related cephalosporin derivatives.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the absorption, distribution, metabolism, and excretion (ADME) profile of ceftiofur.
• Veterinary Drug Development: Employed in the formulation and quality assurance of injectable and intramammary treatments for bacterial infections in livestock.
• Analytical Method Development: Used to validate and calibrate HPLC, LC-MS/MS, and other chromatographic methods for residue testing in food safety programs.
• Microbiological Research: Applied in studies investigating bacterial resistance mechanisms and the efficacy of β-lactam antibiotics.

Basic Information

Product Name	Desfuroyl Ceftiofur
CAS No.	120882-22-6
Molecular Formula	C19H17N5O7S3
Molecular Weight	523.56 g/mol
Synonyms	(6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-methoxyiminoacetyl]amino]-3-[(2-furanylcarbonyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid; Deacetylceftiofur; Desacetylceftiofur; Ceftiofur Metabolite; U-76,252; 7β-[2-(2-Aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]-3-[(2-furanylcarbonyl)thiomethyl]-3-cephem-4-carboxylic Acid
EINECS	Contact for details

Quality Control

Our Desfuroyl Ceftiofur is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting high standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.