Description

Brusatol is a potent and specific natural product inhibitor of the Nrf2 signaling pathway, a key regulator of cellular antioxidant response. This compound is of significant interest in pharmaceutical research and development due to its ability to sensitize cancer cells to chemotherapy and radiotherapy. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and academic research sectors for drug discovery, mechanism of action studies, and as a critical reference standard.

Application

• Pharmaceutical Research: Used as a lead compound or reference standard in the discovery and development of novel anticancer therapeutics.
• Biochemical Research: Employed as a specific molecular tool to inhibit the Nrf2 pathway, studying oxidative stress response, chemoresistance, and cytoprotective mechanisms.
• Oncology Studies: Investigated for its potential to overcome drug resistance in various cancer cell lines by suppressing Nrf2-mediated defense pathways.
• Academic Research: Utilized in university and institutional labs for fundamental studies in cell biology, signaling pathways, and natural product pharmacology.
• Reference Standard: Serves as a high-purity analytical standard for quality control and compound identification in related product manufacturing.

Basic Information

Product Name	Brusatol
CAS No.	120601-66-3
Molecular Formula	C26H32O11
Molecular Weight	520.53 g/mol
Synonyms	Brusatol; (1R,2R,4S,5S,7R,9S,10R,11S,14S,15R)-14-[(2S,3R,4S,5S)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5,9,11,15-pentahydroxy-2,7,12,12-tetramethyl-3,13-dioxapentacyclo[9.3.3.12,5.01,10.04,9]heptadecane-6,16-dione; Bruceantinol; Nrf2 Inhibitor
EINECS	Contact for details

Quality Control

Our Brusatol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing purity, identity, and other critical parameters is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.