Description

Methyl-2-Isocyano-3-(4-Chloro-Phenyl)-Propionate is a versatile and high-value isocyanide building block used in organic synthesis. This compound matters for its critical role in facilitating multi-component reactions, enabling the efficient construction of complex heterocyclic scaffolds and natural product analogs. Pharmaceutical, agrochemical, and advanced material research laboratories need this reagent to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly for anti-infective and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in constructing heterocyclic cores for next-generation herbicides, fungicides, and insecticides.
• Multi-Component Reaction (MCR) Chemistry: Essential reagent for Passerini and Ugi-type reactions to create diverse compound libraries for high-throughput screening.
• Peptidomimetic Research: Serves as a building block for the development of peptide analogs with enhanced metabolic stability.
• Material Science: Intermediate in the synthesis of specialized polymers and ligands for catalytic systems.
• Academic & Contract Research: Fundamental reagent for methodological development in synthetic organic chemistry.

Basic Information

Product Name	Methyl-2-Isocyano-3-(4-Chloro-Phenyl)-Propionate
CAS No.	120314-12-7
Molecular Formula	C11H10ClNO2
Molecular Weight	223.66 g/mol
Synonyms	Methyl 2-Isocyano-3-(4-chlorophenyl)propanoate; 3-(4-Chlorophenyl)-2-isocyanopropanoic Acid Methyl Ester; 2-Isocyano-3-(4-chlorophenyl)propionic Acid Methyl Ester; Methyl 3-(4-Chlorophenyl)-2-isocyanopropionate; (4-Chlorophenyl)-2-isocyanopropionic Acid Methyl Ester; Isocyanide Building Block 120314-12-7
EINECS	Contact for details

Quality Control

Our Methyl-2-Isocyano-3-(4-Chloro-Phenyl)-Propionate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable for advanced intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.