Description

1,4,7,10-Tetraazacyclododecane-1-Carboxaldehyde is a key functionalized macrocyclic ligand, specifically a cyclen derivative, that serves as a critical building block in advanced coordination chemistry. Its primary value lies in its ability to chelate metal ions with high affinity and selectivity, forming stable complexes essential for various high-tech applications. This compound is particularly vital for researchers and manufacturers in the pharmaceutical, diagnostic, and materials science sectors who require precise molecular scaffolds for developing novel agents.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of sophisticated contrast agents for Magnetic Resonance Imaging (MRI), particularly gadolinium-based complexes.
• Diagnostic Agent Development: Used to create chelating platforms for radiolabeling with isotopes (e.g., 64Cu, 68Ga) for Positron Emission Tomography (PET) imaging and targeted radiotherapy.
• Catalysis Research: Serves as a ligand to create highly active and selective metal catalysts for organic transformations and polymerization processes.
• Chemical Sensor Fabrication: Employed in the design of fluorescent or colorimetric sensors for the selective detection of metal ions and anions in analytical chemistry.
• Materials Science: Acts as a functional linker or modifier for surfaces and nanoparticles, enabling the creation of smart materials with specific binding properties.
• Bioconjugation: The aldehyde functional group allows for site-specific conjugation to biomolecules like antibodies or peptides for creating targeted diagnostic and therapeutic conjugates.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1-Carboxaldehyde
CAS No.	120041-13-6
Molecular Formula	C11H22N4O
Molecular Weight	226.32 g/mol
Synonyms	Cyclen-1-carboxaldehyde; 1,4,7,10-Tetraazacyclododecane-1-carbaldehyde; 1-Carboxyaldehyde-1,4,7,10-tetraazacyclododecane; 1-Formyl-1,4,7,10-tetraazacyclododecane; DO1A; Tetraazacyclododecane carboxaldehyde; 1,4,7,10-Tetraazacyclododecane-1-methanal; 1,4,7,10-Tetraazacyclododecan-1-yl-methanone (tautomer)
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1-Carboxaldehyde is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original container. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.