Description

5-Methyl-1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Ol is a specialized pyrazole derivative characterized by its trifluoromethyl and phenyl substituents, which confer unique chemical reactivity and stability. This compound serves as a versatile and high-value building block in advanced organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development teams in the pharmaceutical, agrochemical, and material science industries for creating molecules with enhanced biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyrazole core.
• Material Science Research: Serves as a monomer or functional additive in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probe: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for designing enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Product Name	5-Methyl-1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Ol
CAS No.	119868-25-6
Molecular Formula	C11H9F3N2O
Molecular Weight	242.20 g/mol
Synonyms	4-Hydroxy-5-methyl-1-phenyl-3-(trifluoromethyl)-1H-pyrazole; 5-Methyl-1-phenyl-3-(trifluoromethyl)pyrazol-4-ol; 1H-Pyrazol-4-ol, 5-methyl-1-phenyl-3-(trifluoromethyl)-; 3-Trifluoromethyl-5-methyl-1-phenyl-1H-pyrazol-4-ol; 4-Hydroxy-3-trifluoromethyl-5-methyl-1-phenylpyrazole; 5-Methyl-1-phenyl-3-trifluoromethylpyrazol-4-ol
EINECS	Contact for details

Quality Control

Our 5-Methyl-1-Phenyl-3-(Trifluoromethyl)-1H-Pyrazol-4-Ol is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing including HPLC, NMR, and GC-MS to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our production can adhere to ISO 9001 standards, and custom synthesis is available under cGMP guidelines for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.