Description

Oxacyclotetradecane Erythromycin Derivatives represent a specialized class of advanced pharmaceutical intermediates derived from the macrolide antibiotic erythromycin. These high-purity compounds are critical for the research and development of novel therapeutic agents, particularly in the fields of anti-infectives and targeted drug delivery systems. Pharmaceutical manufacturers, contract research organizations (CROs), and academic research institutions require these derivatives for synthesizing next-generation antibiotics and exploring new pharmacological pathways.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel macrolide antibiotics and semi-synthetic derivatives with improved efficacy or reduced resistance.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new chemical entities targeting bacterial infections.
• Process Development: Serves as a critical reference standard and starting material in the scale-up and optimization of API (Active Pharmaceutical Ingredient) manufacturing processes.
• Bioconjugation Studies: Utilized in the development of antibody-drug conjugates (ADCs) or other targeted therapies where the erythromycin scaffold provides a specific biological activity.
• Analytical Reference Standard: Employed in quality control laboratories for method development, validation, and impurity profiling of related pharmaceutical products.

Basic Information

Product Name	Oxacyclotetradecane Erythromycin Derivatives
CAS No.	119665-77-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Erythromycin derivative, CAS 119665-77-9; Macrolide intermediate; Oxacyclotetradecane derivative; Erythromycin A derivative; 14-membered lactone intermediate; Antibiotic synthesis intermediate; Advanced pharmaceutical intermediate (API intermediate)
EINECS	Contact for details

Quality Control

Our Oxacyclotetradecane Erythromycin Derivatives are manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific client or regulatory standards, including ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.