Description

(S)-1-Tosyl-2-Methylaziridine CAS NO 119461-40-4 is a high-purity, chiral aziridine derivative, a crucial building block in asymmetric synthesis. Its value lies in its role as a versatile electrophilic intermediate for introducing chiral nitrogen-containing motifs into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of nitrogen-containing drug candidates, including protease inhibitors and other biologically active molecules.
• Asymmetric Synthesis: Employed in ring-opening reactions with nucleophiles to create chiral amines and amino alcohols with high enantiomeric purity.
• Agrochemical Research: Used in the development of novel, chiral pesticides and herbicides where specific stereochemistry is critical for activity.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing chiral ligands and organocatalysts used in enantioselective transformations.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research programs.
• Fine Chemical Production: Integral in the multi-step synthesis of complex, high-value specialty chemicals requiring precise stereochemical control.

Basic Information

Product Name	(S)-1-Tosyl-2-Methylaziridine
CAS No.	119461-40-4
Molecular Formula	C10H13NO2S
Molecular Weight	211.28 g/mol
Synonyms	(S)-2-Methyl-1-tosylaziridine; (S)-1-(4-Methylphenylsulfonyl)-2-methylaziridine; (S)-1-(Tosyl)-2-methylaziridine; (S)-2-Methyl-N-tosylaziridine; (2S)-2-Methyl-1-[(4-methylphenyl)sulfonyl]aziridine; (S)-(-)-1-Tosyl-2-methylaziridine; (S)-1-Tosyl-2-methylazacyclopropane; Tosylmethylaziridine (S)-enantiomer
EINECS	Contact for details

Quality Control

Our (S)-1-Tosyl-2-Methylaziridine is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot undergoes comprehensive analytical testing, including chiral HPLC, NMR, and GC/MS, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.