Description

1-Propanone, 2,2-Difluoro-1-(1-Naphthalenyl)- (9Ci) is a specialized fluorinated aromatic ketone building block, valued for its unique structural motif that combines a naphthalene core with a difluoromethyl ketone group. This compound is critical for advanced research and development, particularly in the synthesis of complex molecules where the introduction of fluorine atoms can dramatically alter physical, chemical, and biological properties. It serves as a key intermediate for pharmaceutical chemists and material scientists working on novel active ingredients, agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-inflammatory pathways, where the difluoroketone moiety can enhance metabolic stability and binding affinity.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity imparted by the fluorine-substituted naphthalene structure.
• Material Science Precursor: Serves as a monomer or functionalizing agent in the creation of advanced polymers, liquid crystals, and organic electronic materials with tailored optical and electronic properties.
• Chemical Synthesis Reagent: Employed in organic synthesis for Friedel-Crafts acylation reactions and as a precursor for further functionalization to create libraries of fluorinated compounds for screening.
• Fluorine Chemistry Studies: An important compound for academic and industrial research focused on understanding the effects of fluorine substitution on aromatic systems and ketone reactivity.

Basic Information

Product Name	1-Propanone, 2,2-Difluoro-1-(1-Naphthalenyl)- (9Ci)
CAS No.	119191-48-9
Molecular Formula	C₁₃H₁₀F₂O
Molecular Weight	220.22 g/mol
Synonyms	2,2-Difluoro-1-(naphthalen-1-yl)ethan-1-one; 1-(1-Naphthyl)-2,2-difluoroethanone; 2,2-Difluoro-1-(1-naphthyl)ethanone; α,α-Difluoro-1-naphthyl methyl ketone; 1-Naphthyl-2,2-difluoroethyl ketone; Naphthalen-1-yl(difluoro)methyl ketone; (1-Naphthyl)difluoromethyl ketone
EINECS	Contact for details

Quality Control

Our production of 1-Propanone, 2,2-Difluoro-1-(1-Naphthalenyl)- (9Ci) adheres to a stringent quality management system to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is analyzed using advanced techniques including HPLC, GC, NMR, and MS to confirm identity and quantify purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment, and we support custom purity requirements to meet specific project needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizing agents, strong acids, and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.