Description

2-Pentenal, 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-, (2E)- is a specialized organosilicon-protected aldehyde intermediate of significant value in advanced organic synthesis. This compound matters because it provides a protected, reactive handle for the controlled construction of complex molecules, particularly in the synthesis of pharmaceuticals and fine chemicals. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing carbon chains and introducing functional groups with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of active pharmaceutical ingredients (APIs), particularly for introducing aldehyde functionality in a protected form.
• Asymmetric Synthesis: Serves as a chiral precursor or electrophile in stereoselective reactions, such as aldol additions or nucleophilic attacks, to create molecules with defined three-dimensional structures.
• Natural Product Synthesis: Used in the laboratory synthesis of complex natural products where the (2E)-pentenal moiety is a required structural element.
• Fine Chemical Production: Employed in the manufacture of specialty chemicals, including flavors, fragrances, and advanced materials, where precise molecular architecture is critical.
• Polymer Chemistry: Can act as a monomer or functionalization agent in the development of novel polymers with specific terminal or pendant aldehyde groups.
• Cross-Coupling Reactions: The silyl-protected oxygen and the aldehyde group make it a suitable substrate for various metal-catalyzed coupling reactions to form new carbon-carbon bonds.

Basic Information

Product Name	2-Pentenal, 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-, (2E)-
CAS No.	118635-66-8
Molecular Formula	C11H22O2Si
Molecular Weight	214.38 g/mol
Synonyms	(2E)-5-[(tert-Butyldimethylsilyl)oxy]-2-pentenal; 5-[(tert-Butyldimethylsilyl)oxy]-2-pentenal, (E)-; (E)-5-((tert-Butyldimethylsilyl)oxy)pent-2-enal; 5-(tert-Butyldimethylsiloxy)-2-pentenal; TBDMS-protected 5-hydroxy-2-pentenal; (E)-5-Hydroxy-2-pentenal TBDMS ether; 5-O-TBDMS-(2E)-pentenal; 5-TBDMSO-2-pentenal
EINECS	Contact for details

Quality Control

Our 2-Pentenal, 5-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]-, (2E)- is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for research and process chemistry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The compound is light-sensitive and should be stored away from light. Keep away from strong bases and incompatible materials such as strong oxidizing agents. Under these conditions, the product is stable for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
(E)-Isomer Content (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.