Description

Cyclohexanepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) is a specialized fluorinated ketoester building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors, where the introduction of fluorine atoms is a critical strategy for modulating biological activity and metabolic stability. It is primarily needed by research chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), crop protection agents, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of fluorinated drug candidates, including potential enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and development of novel, fluorinated pesticides and herbicides, where fluorine enhances lipophilicity and environmental stability.
• Advanced Material Precursor: Acts as a monomer or specialty additive in the development of performance polymers and coatings with tailored properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodology development, exploring new fluorination reactions and carbon-carbon bond formations.
• Ligand and Catalyst Synthesis: Utilized as a starting material for creating complex, fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: A valuable reference compound for studying the reactivity and stability of β-keto esters containing α-fluorine substituents.

Basic Information

Product Name	Cyclohexanepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci)
CAS No.	118460-46-1
Molecular Formula	C11H17FO3
Molecular Weight	216.25 g/mol
Synonyms	Ethyl 2-Fluoro-3-oxo-3-cyclohexylpropanoate; 3-Cyclohexyl-2-fluoro-3-oxopropanoic Acid Ethyl Ester; 2-Fluoro-3-oxo-3-cyclohexylpropionic Acid Ethyl Ester; α-Fluoro-β-oxocyclohexanepropanoic Acid Ethyl Ester; Ethyl α-Fluoro-β-oxocyclohexanepropionate; 118460-46-1; 9CI Identifier Compound
EINECS	Contact for details

Quality Control

Our Cyclohexanepropanoic Acid, α-Fluoro-β-Oxo-, Ethyl Ester (9Ci) is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. This material may be moisture-sensitive; keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.