Description

Benzyl (R)-5-Oxotetrahydrofuran-3-Ylcarbamate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. This compound is essential for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and fine chemicals, where stereochemical control is critical for efficacy and safety. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and advanced material sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of protease inhibitors, antiviral agents, and other bioactive molecules requiring the (R)-configured lactone moiety.
• Asymmetric Synthesis: Serves as a versatile precursor for introducing protected amino acid-like structures into more complex targets via further functionalization of the carbamate and lactone groups.
• Peptidomimetic Research: Used in medicinal chemistry for the design and construction of peptide analogs and conformationally constrained scaffolds.
• Agrochemical Development: Employed in the research and production of chiral pesticides and herbicides where specific stereochemistry enhances activity and reduces environmental impact.
• Catalyst and Ligand Synthesis: Acts as a starting material for the preparation of chiral ligands used in asymmetric catalysis.
• Academic & Process R&D: A valuable reagent for methodological development in organic synthesis and scale-up process optimization studies.

Basic Information

Product Name	Benzyl (R)-5-Oxotetrahydrofuran-3-Ylcarbamate
CAS No.	118399-28-3
Molecular Formula	C12H13NO4
Molecular Weight	235.24 g/mol
Synonyms	(R)-Benzyl 5-oxotetrahydrofuran-3-ylcarbamate; (3R)-5-Oxooxolan-3-yl benzylcarbamate; (R)-Benzyl (5-oxotetrahydrofuran-3-yl)carbamate; (R)-3-(Benzyloxycarbonylamino)dihydrofuran-2(3H)-one; Benzyl N-[(3R)-5-oxooxolan-3-yl]carbamate; (R)-3-[(Benzyloxycarbonyl)amino]dihydro-2(3H)-furanone
EINECS	Contact for details

Quality Control

Our Benzyl (R)-5-Oxotetrahydrofuran-3-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.