Description

3-Trifluoromethyl-5A-Cholestan-3-Ol is a high-value, fluorinated sterol derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its unique structure, featuring a trifluoromethyl group, is engineered to impart enhanced metabolic stability and lipophilicity to target molecules, making it a sought-after building block. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, diagnostic probes, and high-performance materials.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new steroid-based drugs and bioactive molecules.
• Medicinal Chemistry Research: Used to introduce fluorine atoms into lead compounds to optimize their pharmacokinetic and pharmacodynamic properties.
• Biochemical Probe Development: Serves as a precursor for labeled compounds used in metabolic pathway studies and receptor binding assays.
• Advanced Material Science: Potential building block for liquid crystals or specialty polymers requiring fluorinated components.
• Academic & Industrial R&D: Employed in exploratory synthetic routes and methodological studies in organic and fluorine chemistry.

Basic Information

Product Name	3-Trifluoromethyl-5A-Cholestan-3-Ol
CAS No.	118143-27-4
Molecular Formula	C₂₈H₄₇F₃O
Molecular Weight	456.67 g/mol
Synonyms	3-(Trifluoromethyl)-5α-cholestan-3-ol; 5α-Cholestan-3-ol, 3-(trifluoromethyl)-; 3-Trifluoromethyl-5α-cholestanol; 3-Trifluoromethylcholestanol; 3-TFM-5α-cholestan-3-ol; 118143-27-4; 3-(Trifluoromethyl)cholestanol
EINECS	Contact for details

Quality Control

Our 3-Trifluoromethyl-5A-Cholestan-3-Ol is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment, supporting rigorous R&D and cGMP-compliant applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and fluorides. For long-term storage, consider holding under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.