Description

1,1,1-Trifluoro-4-(4-Hydroxyphenyl)Butan-2-One is a high-value fluorinated aromatic ketone intermediate. This compound is critical for the synthesis of advanced pharmaceutical and agrochemical active ingredients due to its unique trifluoromethyl and phenolic functional groups. It is primarily sought by R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecules with enhanced biological activity and metabolic stability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and anti-inflammatory drug candidates.
• Agrochemical Synthesis: Used in the development of next-generation herbicides and fungicides, where the trifluoromethyl group improves lipophilicity and biological efficacy.
• Liquid Crystal Materials: Serves as a precursor for fluorinated compounds used in the electronics industry for liquid crystal displays (LCDs).
• Advanced Material Research: Employed in organic synthesis for creating novel polymers and ligands with specific electronic or optical properties.
• Chemical Biology Probes: Utilized in research to develop fluorinated probes and tags for studying biological systems and drug-target interactions.

Basic Information

Product Name	1,1,1-Trifluoro-4-(4-Hydroxyphenyl)Butan-2-One
CAS No.	117896-99-8
Molecular Formula	C10H9F3O2
Molecular Weight	218.17 g/mol
Synonyms	4'-Hydroxy-4,4,4-trifluorobutyrophenone; 4-(4-Hydroxyphenyl)-1,1,1-trifluorobutan-2-one; 1,1,1-Trifluoro-4-(4-hydroxyphenyl)-2-butanone; 4,4,4-Trifluoro-1-(4-hydroxyphenyl)-2-butanone; TFHPB; p-Hydroxy-α-trifluoromethylpropiophenone
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-(4-Hydroxyphenyl)Butan-2-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.