Description

6-Quinazolinecarbonitrile, 3,4-Dihydro-4-Oxo- is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 117297-41-3. This heterocyclic nitrile compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, particularly kinase inhibitors. It is essential for research and development chemists and process engineers in the pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and active pharmaceutical ingredient (API) manufacturing.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel quinazoline-based kinase inhibitors for oncology and other therapeutic areas.
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Chemical Synthesis: Serves as a versatile building block for constructing complex heterocyclic scaffolds in organic and process chemistry.
• Biochemical Research: Employed in the development of enzyme inhibitors and probes for biological pathway analysis.
• Custom Synthesis: A starting material for the contract manufacturing of specialized fine chemicals and APIs.

Basic Information

Product Name	6-Quinazolinecarbonitrile, 3,4-Dihydro-4-Oxo-
CAS No.	117297-41-3
Molecular Formula	C10H5N3O
Molecular Weight	183.17 g/mol
Synonyms	4-Oxo-3,4-dihydroquinazoline-6-carbonitrile; 3,4-Dihydro-4-oxoquinazoline-6-carbonitrile; 6-Cyano-3,4-dihydro-4-oxoquinazoline; 4-Oxo-1,4-dihydroquinazoline-6-carbonitrile; Quinazoline-6-carbonitrile, 3,4-dihydro-4-oxo-; 117297-41-3; 6-Quinazolinecarbonitrile, 3,4-dihydro-4-oxo-
EINECS	Contact for details

Quality Control

Our 6-Quinazolinecarbonitrile, 3,4-Dihydro-4-Oxo- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.