Description

4-(2'-Pyridyldithio)Benzyldiazoacetate is a specialized heterobifunctional crosslinking reagent featuring a diazoacetate group and a pyridyl disulfide moiety. This compound is engineered for the controlled conjugation of biomolecules, enabling the formation of stable thioether bonds under mild conditions. It is a critical tool for researchers and manufacturers in bioconjugation, antibody-drug conjugate (ADC) development, and advanced pharmaceutical synthesis, where precise and stable linkage chemistry is paramount.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: For the site-specific conjugation of cytotoxic payloads to monoclonal antibodies via its reactive functional groups.
• Protein and Peptide Modification: Used to introduce functional handles or labels onto cysteine-containing proteins for diagnostics or therapeutic applications.
• Surface Immobilization: Enables the covalent attachment of biomolecules to solid supports (e.g., sensor chips, nanoparticles, resins) for assay development and drug delivery systems.
• Polymer Functionalization: Acts as a key intermediate for synthesizing smart polymers and hydrogels with cleavable or responsive linkages.
• Biomaterial Engineering: Facilitates the creation of bioactive scaffolds for tissue engineering and regenerative medicine.
• Diagnostic Reagent Synthesis: Employed in the production of enzyme conjugates and labeled probes for immunoassays and molecular imaging.

Basic Information

Product Name	4-(2'-Pyridyldithio)Benzyldiazoacetate
CAS No.	117141-32-9
Molecular Formula	C15H11N3O2S2
Molecular Weight	329.40 g/mol
Synonyms	2-Pyridyldithio Benzyldiazoacetate; 4-(Pyridin-2-yldisulfanyl)benzyl diazoacetate; Benzyldiazoacetate 2-pyridyl disulfide; PDBA; 4-(2-PDS)Benzyldiazoacetate; 4-(2-Pyridyldithio)benzyl 2-diazoacetate; α-Diazo-4-[(2-pyridinyldithio)methyl]benzeneacetate
EINECS	Contact for details

Quality Control

Our 4-(2'-Pyridyldithio)Benzyldiazoacetate is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and performance consistency suitable for research and bioconjugation applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the container to reach room temperature in a desiccator before opening to prevent moisture condensation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.