Description

3-(2'-Pyridyldithio)Benzyldiazoacetate is a specialized bifunctional chemical reagent featuring both a diazoacetate group and a pyridyl disulfide moiety. This unique structure makes it a valuable tool for site-specific conjugation and crosslinking applications in advanced material and bioconjugate synthesis. It is primarily utilized by researchers and process development chemists in the pharmaceutical and biotechnology sectors. The compound enables controlled chemical modifications under mild conditions, facilitating the development of targeted drug delivery systems and functionalized biomaterials.

Application

• Bioconjugation Reagent: For the site-specific modification of proteins, antibodies, and peptides via disulfide exchange or carbene insertion chemistry.
• Linker in ADC Development: As a cleavable linker component in the synthesis of Antibody-Drug Conjugates (ADCs) for targeted cancer therapies.
• Polymer Functionalization: To introduce reactive handles onto polymer backbones for creating smart materials and hydrogels.
• Surface Immobilization: For covalently attaching biomolecules to chips, beads, or other solid supports for biosensor and diagnostic assay development.
• Crosslinking Agent: In the preparation of crosslinked protein or polymer networks with controlled stability.
• Chemical Biology Probes: As a key building block for synthesizing activity-based probes to study enzyme function.

Basic Information

Product Name	3-(2'-Pyridyldithio)Benzyldiazoacetate
CAS No.	117141-31-8
Molecular Formula	C₁₅H₁₁N₃O₂S₂
Molecular Weight	329.40 g/mol
Synonyms	PDBDA; 2-Pyridyldithio Benzyldiazoacetate; Benzyldiazoacetate 3-(2-pyridyldithio); Diazoacetic Acid 3-(2-Pyridyldithio)benzyl Ester; 3-(Pyrid-2-yldithio)benzyldiazoacetate; (3-((2-Pyridinyldithio)methyl)phenyl)diazoacetate; SPDP-Diazoacetate Analog; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our 3-(2'-Pyridyldithio)Benzyldiazoacetate is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and process development. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation and degradation. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.