Description

(2R,4S,5R)-4-(Hydroxymethyl)-2-Phenyl-1,3-Dioxan-5-Ol is a high-value chiral building block and protected sugar derivative. This compound is essential for the synthesis of complex molecules, offering precise stereochemical control that is critical in advanced pharmaceutical and fine chemical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing nucleoside analogs, antiviral agents, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of nucleoside-based antiviral and anticancer drugs.
• Asymmetric Synthesis: Used as a building block for constructing complex natural products and active pharmaceutical ingredients (APIs) with defined stereochemistry.
• Carbohydrate Chemistry: Serves as a protected sugar derivative for the synthesis of modified sugars, glycosides, and oligonucleotide analogs.
• Agrochemical Research: Employed in the development of novel chiral pesticides and herbicides where specific stereoisomers exhibit enhanced activity.
• Material Science: Potential monomer for creating novel polymers with specific chiral architectures.
• Academic & Contract Research: A valuable reagent for methodological studies in organic synthesis and catalysis within university and CRO laboratories.

Basic Information

Product Name	(2R,4S,5R)-4-(Hydroxymethyl)-2-Phenyl-1,3-Dioxan-5-Ol
CAS No.	117122-84-6
Molecular Formula	C12H16O4
Molecular Weight	224.25 g/mol
Synonyms	2-Phenyl-1,3-dioxane-4,5-dimethanol, (4R,5S)-rel-; (4R,5S)-4,5-Bis(hydroxymethyl)-2-phenyl-1,3-dioxane; (2R,4S,5R)-2-Phenyl-1,3-dioxane-4,5-dimethanol; 2-Phenyl-4,5-bis(hydroxymethyl)-1,3-dioxane; Phenylboronic acid 1,3-dioxane acetal derivative; Chiral dioxane acetal; Protected glyceryl acetal.
EINECS	Contact for details

Quality Control

Our (2R,4S,5R)-4-(Hydroxymethyl)-2-Phenyl-1,3-Dioxan-5-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and stereochemical purity suitable for sensitive synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.