Description

Cyclobutanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-, trans- (9Ci) is a high-purity, functionalized cyclobutane derivative of significant interest in advanced organic synthesis. This compound matters as a sophisticated chiral building block, offering a rigid, strained four-membered ring scaffold that is crucial for modulating the three-dimensional structure and biological activity of target molecules. It is primarily needed by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by academic and industrial researchers in medicinal chemistry exploring new chemical space.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in protease inhibitor and antiviral research.
• Medicinal Chemistry Building Block: Used to introduce conformational constraint into lead compounds, potentially improving potency, selectivity, and metabolic stability.
• Agrochemical Synthesis: Serves as a precursor in the development of new herbicides or fungicides with unique modes of action.
• Peptidomimetics Research: The trans-1,3-disubstituted cyclobutane core is valuable for creating rigid peptide analogs and foldamers.
• Ligand and Catalyst Development: Utilized in the preparation of novel chiral ligands for asymmetric catalysis.
• Material Science Precursor: Potential use in synthesizing specialty monomers for advanced polymers.

Basic Information

Product Name	Cyclobutanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-, trans- (9Ci)
CAS No.	116823-32-6
Molecular Formula	C6H11NO3
Molecular Weight	145.16 g/mol
Synonyms	trans-1-Amino-3-(hydroxymethyl)cyclobutanecarboxylic Acid; (1R,3S)-1-Amino-3-(hydroxymethyl)cyclobutanecarboxylic Acid; (1S,3R)-1-Amino-3-(hydroxymethyl)cyclobutanecarboxylic Acid; trans-ACHC-OH; ABCHC; 1-Amino-3-(hydroxymethyl)cyclobutanecarboxylic acid, trans-; (1-Amino-3-hydroxy-methyl-cyclobutyl)-acetic acid
EINECS	Contact for details

Quality Control

Our Cyclobutanecarboxylic Acid, 1-Amino-3-(Hydroxymethyl)-, trans- (9Ci) is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (trans isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.