Description

5-Bromo-2-Iodotoluene is a halogenated toluene derivative of significant importance as a versatile synthetic intermediate in advanced organic chemistry. Its value lies in the strategic positioning of bromine and iodine atoms on the aromatic ring, which allows for selective, sequential cross-coupling reactions, such as Suzuki and Sonogashira couplings. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, leveraging its reactivity to create complex bioactive molecules.
• Material Science Precursor: Serves as a monomer or functionalization agent in the production of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An essential substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Sonogashira couplings to form biaryl and alkyne structures.
• Chemical Research & Development: Employed in academic and industrial labs for methodological studies and the exploration of new synthetic pathways.
• Ligand and Catalyst Preparation: Used to synthesize sophisticated ligands for metal complexes and catalysts used in asymmetric synthesis.

Basic Information

Product Name	5-Bromo-2-Iodotoluene
CAS No.	116632-39-4
Molecular Formula	C7H6BrI
Molecular Weight	296.93 g/mol
Synonyms	2-Iodo-5-bromotoluene; 1-Bromo-4-iodo-2-methylbenzene; 5-Bromo-2-iodo-1-methylbenzene; Toluene, 5-bromo-2-iodo-; 2-Methyl-5-bromo-1-iodobenzene; 5-Bromo-o-iodotoluene; 2-Iodo-5-methylbromobenzene
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Iodotoluene is manufactured under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.