Description

Methyl (1R,4Ar,5S,8R,8Ar)-8-Benzoyloxy-5-(3-Formylbut-3-Enyl)-4A-Methyl-6-Methylidene-Decalin-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its complex decalin-based structure with multiple chiral centers. This compound is of significant value for its role as a key synthetic precursor in the development of complex organic molecules, particularly in medicinal chemistry. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents, including anti-inflammatory and anti-cancer candidates.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), especially those with steroidal or terpenoid-like frameworks.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with targeted biological activity.
• Process Chemistry Development: Serves as a model compound or intermediate for developing and scaling up efficient, stereoselective synthetic routes in pilot plants.
• Academic & Industrial R&D: Employed in organic synthesis laboratories for exploring new chemical reactions, catalysis, and methodology development due to its challenging molecular architecture.
• Precursor for Specialty Chemicals: Can be further functionalized to create specialized ligands, chiral auxiliaries, or fragrances requiring a rigid decalin core.

Basic Information

Product Name	Methyl (1R,4Ar,5S,8R,8Ar)-8-Benzoyloxy-5-(3-Formylbut-3-Enyl)-4A-Methyl-6-Methylidene-Decalin-1-Carboxylate
CAS No.	116425-28-6
Molecular Formula	C26H32O5
Molecular Weight	424.53 g/mol
Synonyms	Methyl 8-benzoyloxy-5-(3-formylbut-3-enyl)-4a-methyl-6-methylidenedecalin-1-carboxylate; (1R,4aR,5S,8R,8aR)-Methyl 8-(benzoyloxy)-5-[(3-formylbut-3-en-1-yl)]-4a-methyl-6-methylidene-1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalene-1-carboxylate; CAS 116425-28-6; Decalin-1-carboxylic acid derivative; Benzoyloxy decalin carboxylate intermediate
EINECS	Contact for details

Quality Control

Our Methyl (1R,4Ar,5S,8R,8Ar)-8-Benzoyloxy-5-(3-Formylbut-3-Enyl)-4A-Methyl-6-Methylidene-Decalin-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically ≥95% by HPLC), and specific tests is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be sensitive to moisture and oxidation; prolonged exposure to air should be avoided.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% de
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.