Description

1-(4-Difluoromethoxy-3-Methylphenyl)-Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct difluoromethoxy and methylphenyl ketone structure. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modifications. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the difluoromethoxy group for enhanced biological activity and stability.
• Organic Synthesis Research: Serves as a versatile precursor in academic and industrial laboratories for constructing complex aromatic ketone frameworks.
• Material Science: Investigated for the development of specialty polymers and liquid crystals where specific fluorine-containing aromatic units are required.
• Fluorine Chemistry Studies: An important compound for studying the effects of fluorine substitution on the reactivity and properties of aromatic ketones.

Basic Information

Product Name	1-(4-Difluoromethoxy-3-Methylphenyl)-Ethanone
CAS No.	116400-19-2
Molecular Formula	C10H10F2O2
Molecular Weight	200.18 g/mol
Synonyms	4'-Difluoromethoxy-3'-Methylacetophenone; 1-Acetyl-4-(difluoromethoxy)-3-methylbenzene; 3-Methyl-4-(difluoromethoxy)acetophenone; Ethanone, 1-[4-(difluoromethoxy)-3-methylphenyl]-; 4-(Difluoromethoxy)-3-methylacetophenone; 1-(4-(Difluoromethoxy)-3-methylphenyl)ethan-1-one
EINECS	Contact for details

Quality Control

Our 1-(4-Difluoromethoxy-3-Methylphenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.