Description

(S)-3-Boc-Amino-1-Diazo-5-Methyl-2-Hexanone CAS NO 116300-00-6 is a high-purity, chiral diazo compound featuring a tert-butoxycarbonyl (Boc) protected amine group. This specialized building block is critical for the synthesis of complex, optically active molecules, offering precise stereochemical control in advanced organic transformations. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), peptide mimetics, and other fine chemicals where structural complexity and chirality are paramount.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptidomimetic Research: Used to introduce constrained, non-natural amino acid analogs into peptide backbones for structure-activity relationship (SAR) studies.
• Asymmetric Synthesis: Serves as a precursor for metal-catalyzed reactions, such as cyclopropanations or X-H insertions, to construct chiral centers.
• Chemical Biology Probes: Employed in the development of photoaffinity labeling agents or activity-based probes due to the reactive diazo functionality.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic chemistry and for scaling up synthetic routes in process R&D.
• Agrochemical Research: Potential intermediate in the synthesis of chiral, biologically active compounds for crop protection.

Basic Information

Product Name	(S)-3-Boc-Amino-1-Diazo-5-Methyl-2-Hexanone
CAS No.	116300-00-6
Molecular Formula	C₁₂H₂₁N₃O₃
Molecular Weight	255.32 g/mol
Synonyms	(S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-5-methyl-2-hexanone; (S)-1-Diazo-3-[(tert-butoxycarbonyl)amino]-5-methyl-2-hexanone; Boc-L-β-diazoalanine isopropyl ketone; (S)-3-(Boc-amino)-1-diazo-5-methylhexan-2-one; tert-Butyl (S)-(1-diazo-5-methyl-1-oxohexan-3-yl)carbamate; (S)-3-(tert-Butoxycarbonylamino)-1-diazo-5-methylhexan-2-one
EINECS	Contact for details

Quality Control

Our (S)-3-Boc-Amino-1-Diazo-5-Methyl-2-Hexanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation due to its light-sensitive and easily oxidized nature. Allow the container to reach room temperature in a desiccator before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.