Description

Proline, 4-Hydroxy-5-Oxo-, Ethyl Ester, cis- (9Ci) is a specialized proline derivative, a key chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of pharmaceuticals and bioactive compounds. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the synthesis of novel drug candidates, particularly protease inhibitors and other biologically active molecules.
• Peptidomimetics Research: Used in the design and construction of peptidomimetics, where its modified proline scaffold helps mimic peptide structures for enhanced stability and bioavailability.
• Asymmetric Catalysis: Acts as a precursor or ligand in the development of chiral catalysts for stereoselective chemical transformations.
• Agrochemical Synthesis: Employed in the research and development of advanced, enantiomerically pure agrochemicals.
• Academic & Institutional Research: A valuable reagent for universities and research institutes studying heterocyclic chemistry, amino acid derivatives, and synthetic methodology.
• Fine Chemical Production: Used in the custom synthesis of high-value, specialty chemicals for various industrial applications.

Basic Information

Product Name	Proline, 4-Hydroxy-5-Oxo-, Ethyl Ester, cis- (9Ci)
CAS No.	115223-51-3
Molecular Formula	C8H11NO4
Molecular Weight	185.18 g/mol
Synonyms	cis-4-Hydroxy-5-oxoproline ethyl ester; Ethyl cis-4-hydroxy-5-oxo-2-pyrrolidinecarboxylate; (2S,4R)-4-Hydroxy-5-oxoproline ethyl ester; 4-Hydroxy-5-oxo-L-proline ethyl ester; L-Proline, 4-hydroxy-5-oxo-, ethyl ester, cis-; Ethyl 4-hydroxy-5-oxoproline; 5-Oxo-4-hydroxyproline ethyl ester
EINECS	Contact for details

Quality Control

Our Proline, 4-Hydroxy-5-Oxo-, Ethyl Ester, cis- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and chiral integrity is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.