Description

3-Chloro-3-[4-(Trifluoromethyl)Phenyl]-3H-Diazirine is a highly specialized photolabile carbene precursor, a member of the diazirine class of compounds. Its core value lies in its ability to generate highly reactive carbene intermediates upon photolysis with UV light, enabling efficient and controlled cross-linking and labeling in complex molecular systems. This compound is essential for researchers and manufacturers in pharmaceutical development, chemical biology, and materials science who require precise photoaffinity labeling, surface modification, or polymer cross-linking.

Application

• Photoaffinity Labeling (PAL): A critical tool in drug discovery and proteomics for mapping ligand-protein interactions and identifying biological targets.
• Surface Functionalization: Used to create reactive monolayers on metals, polymers, and glass for biosensor and microarray development.
• Polymer Cross-Linking Agent: Imparts specific mechanical and chemical properties to advanced polymeric materials through UV-initiated curing.
• Bioconjugation: Facilitates the site-specific attachment of probes, drugs, or other molecules to proteins, antibodies, and nucleic acids.
• Materials Science Research: Employed in the synthesis of novel organic frameworks and the study of carbene insertion reactions.
• Chemical Biology Probes: Serves as a key building block for creating activity-based probes to study enzyme function and metabolic pathways.

Basic Information

Product Name	3-Chloro-3-[4-(Trifluoromethyl)Phenyl]-3H-Diazirine
CAS No.	115127-52-1
Molecular Formula	C9H5ClF3N2
Molecular Weight	233.60 g/mol
Synonyms	3-Chloro-3-[4-(trifluoromethyl)phenyl]diazirine; 3-Chloro-3-(4-trifluoromethylphenyl)diazirine; 3-Chloro-3-(α,α,α-trifluoro-p-tolyl)diazirine; 3-Chloro-3-(4-(trifluoromethyl)phenyl)diaziridine; 3H-Diazirine, 3-chloro-3-[4-(trifluoromethyl)phenyl]-; p-Trifluoromethylphenylchlorodiazirine; Photoaffinity Labeling Reagent; Carbene Precursor
EINECS	Contact for details

Quality Control

Our 3-Chloro-3-[4-(Trifluoromethyl)Phenyl]-3H-Diazirine is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot is characterized by multiple analytical techniques to confirm identity and purity, meeting the stringent requirements of research and development applications. Certificates of Analysis (COA) detailing purity, spectral data, and stability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at recommended temperatures between -20°C to -10°C for long-term stability. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when possible to prevent decomposition. Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Yellow to orange crystalline solid or solution
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Solvent (if supplied as solution)	Toluene, Hexane, or as specified
Concentration (if supplied as solution)	0.1M or as specified

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.