Description

Diethyl 2-(Acetylamino)-2-[4-(Trifluoromethyl)Benzyl]Malonate is a high-value, multifunctional chemical intermediate characterized by its malonate ester core and trifluoromethylbenzyl moiety. This compound is essential for synthetic chemists as it provides a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D laboratories and production facilities in the life sciences sector for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides and pesticides, leveraging the biological activity of the trifluoromethyl group.
• Material Science Research: Serves as a precursor for specialty monomers and polymers with unique fluorinated properties for high-performance materials.
• Chemical Biology & Proteomics: Employed as a scaffold or linker in the development of chemical probes and enzyme inhibitors for biological pathway studies.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis projects requiring the introduction of a protected amino acid-like structure.

Basic Information

Product Name	Diethyl 2-(Acetylamino)-2-[4-(Trifluoromethyl)Benzyl]Malonate
CAS No.	114872-59-2
Molecular Formula	C17H20F3NO5
Molecular Weight	375.34 g/mol
Synonyms	Diethyl (Acetylamino)(4-(trifluoromethyl)benzyl)malonate; 2-(Acetylamino)-2-[4-(trifluoromethyl)benzyl]malonic Acid Diethyl Ester; Diethyl N-Acetyl-α-(4-trifluoromethylbenzyl)aminomalonate; Acetylaminomalonic Acid Diethyl Ester 4-Trifluoromethylbenzyl Derivative; Ethyl 2-(Acetylamino)-2-((4-(trifluoromethyl)phenyl)methyl)malonate; 114872-59-2; ATBMA
EINECS	Contact for details

Quality Control

Our Diethyl 2-(Acetylamino)-2-[4-(Trifluoromethyl)Benzyl]Malonate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, confirming compliance with customer specifications and industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.