Description

Ethanone, 2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci) is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its core value lies in the unique reactivity imparted by the difluoroacetyl group adjacent to an aromatic ring, enabling precise molecular construction. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly those requiring a difluoromethyl ketone moiety for bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance lipophilicity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, contributing unique electronic and structural properties.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, nucleophilic additions, and as a precursor for heterocyclic compounds in academic and industrial research settings.
• Fluorine Chemistry Research: An important compound for studying the effects of gem-difluoro substitution on reaction pathways and physical properties in aromatic systems.

Basic Information

Product Name	Ethanone, 2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci)
CAS No.	114829-07-1
Molecular Formula	C9H8F2O2
Molecular Weight	186.16 g/mol
Synonyms	2,2-Difluoro-1-(4-methoxyphenyl)ethanone; 4-Methoxy-α,α-difluoroacetophenone; 1-(4-Methoxyphenyl)-2,2-difluoroethanone; p-Methoxy-α,α-difluoroacetophenone; 4-Methoxybenzoylfluoromethane; Difluoro(4-methoxyphenyl)methanone; (4-Methoxyphenyl)difluoromethyl ketone
EINECS	Contact for details

Quality Control

Our Ethanone, 2,2-Difluoro-1-(4-Methoxyphenyl)- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.