Description

2-(Cbz-Amino)Acetaldehyde Dimethyl Acetal is a protected amino aldehyde derivative, serving as a versatile and critical building block in advanced organic synthesis. Its primary value lies in providing a masked aldehyde functionality that is stable under basic conditions, enabling controlled deprotection for the selective introduction of amino aldehyde moieties. This compound is essential for researchers and manufacturers in the pharmaceutical and fine chemical industries, particularly for the synthesis of complex molecules, peptide mimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those containing amino acid or peptide-like structures.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis to introduce specific aldehyde handles for conjugation or further functionalization.
• Protecting Group Strategy: The Cbz (carboxybenzyl) group provides orthogonal protection for amines, while the acetal protects the aldehyde, allowing for sequential deprotection in multi-step syntheses.
• Ligand and Catalyst Synthesis: Employed in the preparation of chiral ligands, organocatalysts, and other specialty chemicals requiring precise molecular architecture.
• Bioconjugation: Useful for creating linkers and modifying biomolecules where a stable, protected form of an amino aldehyde is required prior to reaction.
• Academic and R&D: A valuable reagent for methodological development and exploring new synthetic pathways in university and industrial research laboratories.

Basic Information

Product Name	2-(Cbz-Amino)Acetaldehyde Dimethyl Acetal
CAS No.	114790-39-5
Molecular Formula	C₁₂H₁₇NO₄
Molecular Weight	239.27 g/mol
Synonyms	N-Cbz-2-Aminoacetaldehyde Dimethyl Acetal; N-[(Benzyloxy)carbonyl]-2-aminoacetaldehyde Dimethyl Acetal; (2,2-Dimethoxyethyl)carbamic Acid Benzyl Ester; N-Carbobenzoxy-2-aminoacetaldehyde Dimethyl Acetal; N-Z-2-Aminoacetaldehyde Dimethyl Acetal; Z-NH-CH2-CH(OCH3)2; Benzyl N-(2,2-dimethoxyethyl)carbamate
EINECS	Contact for details

Quality Control

Our 2-(Cbz-Amino)Acetaldehyde Dimethyl Acetal is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and cGMP manufacturing. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound is moisture-sensitive; keep the container tightly sealed in a dry environment to prevent hydrolysis of the acetal group.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.