Description

n-α-T-Butyloxycarbonyl-L-Isoleucinyl-Diazomethane, (3S,4S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Hexanone CAS NO 114645-19-1 is a specialized, high-purity chiral diazoketone derivative used as a critical building block in advanced organic synthesis. Its value lies in its role as a versatile precursor for peptide coupling and the synthesis of complex, stereochemically defined molecules. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly for creating novel active pharmaceutical ingredients (APIs) and exploring new synthetic methodologies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex peptide-based drugs and novel therapeutic agents.
• Peptide Chemistry: Used in peptide coupling reactions to introduce specific amino acid residues under mild conditions.
• Chemical Biology Probes: Enables the creation of photoaffinity labels and activity-based probes for studying enzyme mechanisms and protein interactions.
• Asymmetric Synthesis: Serves as a chiral building block for constructing molecules with defined stereochemistry, crucial for drug efficacy.
• API Development: Employed in research-scale and process development for new Active Pharmaceutical Ingredients (APIs).
• Academic & Industrial R&D: A valuable tool for methodology development in organic chemistry laboratories.

Basic Information

Product Name	n-α-T-Butyloxycarbonyl-L-Isoleucinyl-Diazomethane, (3S,4S)-3-Boc-Amino-1-Diazo-4-Methyl-2-Hexanone
CAS No.	114645-19-1
Molecular Formula	C17H29N3O5
Molecular Weight	355.43 g/mol
Synonyms	(3S,4S)-3-[(tert-Butoxycarbonyl)amino]-1-diazo-4-methyl-2-hexanone; Boc-L-Isoleucinyl-Diazomethane; N-α-Boc-L-Isoleucine Diazomethyl Ketone; Boc-Ile-CHN2; (3S,4S)-3-(Boc-amino)-1-diazo-4-methylhexan-2-one; tert-Butyl (1S,2S)-1-((diazoacetyl)methyl)-2-methylbutylcarbamate; L-Isoleucine, N-[(1,1-dimethylethoxy)carbonyl]-, diazomethyl ketone
EINECS	Contact for details

Quality Control

Our n-α-T-Butyloxycarbonyl-L-Isoleucinyl-Diazomethane is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, chiral integrity, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation due to its light-sensitive and easily oxidized nature. Allow the container to reach room temperature in a desiccator before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.