Description

(S)-3-Boc-Amino-1-Diazo-3-(4'-Benzyloxy)Phenyl-2-Butanone is a sophisticated chiral building block and diazo compound of significant interest in advanced organic synthesis. Its value lies in its dual functionality, serving as a key precursor for the stereoselective construction of complex nitrogen-containing heterocycles and β-amino acid derivatives. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel APIs, especially those containing β-amino acid motifs or complex heterocyclic structures.
• Asymmetric Synthesis: Utilized in stereoselective reactions, including cyclopropanation and C-H insertion reactions, facilitated by the reactive diazo group and protected amine.
• Peptidomimetic Research: Serves as a building block for creating peptidomimetics and constrained peptides to enhance metabolic stability and bioavailability in drug candidates.
• Agrochemical Synthesis: Used in the development of new chiral pesticides and herbicides where specific stereochemistry is crucial for biological activity.
• Academic & Process Chemistry: A valuable reagent for methodological development in organic chemistry and for scaling up synthetic routes in process chemistry.
• Ligand & Catalyst Development: Can be employed in the synthesis of novel chiral ligands and organocatalysts for asymmetric transformations.

Basic Information

Product Name	(S)-3-Boc-Amino-1-Diazo-3-(4'-Benzyloxy)Phenyl-2-Butanone
CAS No.	114645-18-0
Molecular Formula	C22H25N3O4
Molecular Weight	395.46 g/mol
Synonyms	(S)-1-Diazo-3-[(tert-butoxycarbonyl)amino]-3-[4-(benzyloxy)phenyl]butan-2-one; (S)-3-(Boc-Amino)-1-diazo-3-(4-benzyloxyphenyl)-2-butanone; (S)-3-(tert-Butoxycarbonylamino)-1-diazo-3-(4-benzyloxyphenyl)butan-2-one; (S)-3-(N-Boc-Amino)-1-diazo-3-(4-benzyloxyphenyl)-2-butanone; Boc-Dap(Bzl)-diazo ketone; (S)-1-Diazo-3-(N-Boc-amino)-3-(4-benzyloxyphenyl)-2-butanone; (S)-3-Amino-3-[4-(benzyloxy)phenyl]-1-diazo-2-butanone tert-butyl carbamate
EINECS	Contact for details

Quality Control

Our (S)-3-Boc-Amino-1-Diazo-3-(4'-Benzyloxy)Phenyl-2-Butanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C or as indicated on the label or COA. For prolonged storage, consider storage under an inert atmosphere. Keep container tightly sealed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.