Description

Brusatol is a potent and specific natural product inhibitor of the Nrf2 signaling pathway, a key regulator of cellular antioxidant response. This compound is of significant interest for its ability to sensitize cancer cells to chemotherapy and radiotherapy by disrupting cellular defense mechanisms. It serves as a critical research tool for scientists in oncology, pharmacology, and molecular biology, enabling the study of oxidative stress, chemoresistance, and novel therapeutic strategies. Brusatol CAS NO 114420-67-6 is supplied to meet the stringent requirements of advanced life science research and pre-clinical development.

Application

• Oncology Research: Used as a chemosensitizer to study and overcome multidrug resistance (MDR) in various cancer cell lines.
• Molecular Biology Studies: A key pharmacological tool for investigating the Nrf2-Keap1 pathway and its role in cellular protection against oxidative and electrophilic stress.
• Drug Discovery & Development: Employed in high-throughput screening and pre-clinical studies to evaluate combination therapies and novel anti-cancer agents.
• Biochemical Assays: Utilized in vitro to inhibit protein synthesis and study downstream effects on gene expression related to metabolism and detoxification.
• Academic & Pharmaceutical R&D: Supports fundamental research into diseases where oxidative stress and inflammation are contributing factors.

Basic Information

Product Name	Brusatol
CAS No.	114420-67-6
Molecular Formula	C26H32O11
Molecular Weight	520.53 g/mol
Synonyms	Bruceantin analog; (3aS,4R,5S,6aR,7R,8S,9S,11aR,11bS)-8-[(2S,3R,4S,5S,6R)-3,4-Dihydroxy-6-methyl-5-[(2-methyl-1-oxobutanoyl)oxy]oxan-2-yl]oxy-4,5,7,9,11a,11b-hexahydro-3a,7,9-trihydroxy-6a-methyl-3H-furo[4,3,2-de]indeno[5,4-b]furan-2,10-dione; Nrf2 Inhibitor
EINECS	Contact for details

Quality Control

Our Brusatol is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the exact specifications and test results. We support research compliance with traceable documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is sealed tightly after each use to minimize exposure to moisture and light. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.