Description

L-Serine, 2-Methyl-, Methyl Ester, Hydrochloride is a protected amino acid derivative, specifically the methyl ester hydrochloride salt of 2-methyl-L-serine. This compound is a crucial chiral building block in organic synthesis, offering a reactive ester group and a protected amine for controlled peptide and peptidomimetic construction. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, bioactive peptides, and complex organic molecules where precise stereochemistry is essential.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, particularly in oncology and metabolic disease research.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the 2-methyl-serine moiety, which can modulate peptide stability and bioactivity.
• Proteomics Research: Serves as a standard or building block in the study of post-translational modifications and protein engineering.
• Chemical Biology: Employed in the design and synthesis of enzyme inhibitors, receptor ligands, and molecular probes.
• Agrochemical Development: Potential intermediate in the synthesis of advanced, chiral active ingredients for crop protection.
• Academic Research: Fundamental building block in university and institutional labs for methodological development in asymmetric synthesis.

Basic Information

Product Name	L-Serine, 2-Methyl-, Methyl Ester, Hydrochloride
CAS No.	114396-63-3
Molecular Formula	C5H12ClNO3
Molecular Weight	169.61 g/mol
Synonyms	(2S)-2-Amino-3-methoxy-2-methylpropanoic acid hydrochloride; Methyl (2S)-2-amino-3-methoxy-2-methylpropanoate hydrochloride; 2-Methyl-L-serine methyl ester hydrochloride; O-Methyl-2-methyl-L-serine hydrochloride; (S)-2-Amino-3-methoxy-2-methylpropionic acid methyl ester hydrochloride; L-2-Methylserine methyl ester HCl; 2-Methylserine O-methyl ester hydrochloride
EINECS	Contact for details

Quality Control

Our L-Serine, 2-Methyl-, Methyl Ester, Hydrochloride is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and advanced synthesis. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.