Description

5-Bromo-1-Diethoxyphosphinyl-4-Hydroxypentan-2-One is a high-value organophosphorus intermediate with a reactive bromo and hydroxypentanone moiety. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting kinase inhibition or other phosphonate-containing therapeutics.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral phosphine ligands and organocatalysts used in asymmetric synthesis.
• Peptide Mimetics & Prodrug Development: The phosphinyl and bromo groups make it valuable for creating phosphate prodrugs and bioisosteres in medicinal chemistry.
• Material Science Research: Employed in the development of specialty polymers and functional materials with specific phosphorus-based properties.
• Chemical Biology Probes: Useful for synthesizing activity-based probes to study enzyme function and biological pathways.

Basic Information

Product Name	5-Bromo-1-Diethoxyphosphinyl-4-Hydroxypentan-2-One
CAS No.	113848-03-6
Molecular Formula	C9H18BrO5P
Molecular Weight	317.12 g/mol
Synonyms	5-Bromo-4-hydroxy-1-diethoxyphosphorylpentan-2-one; 4-Hydroxy-5-bromo-1-diethoxyphosphorylpentan-2-one; 1-Diethoxyphosphoryl-5-bromo-4-hydroxypentan-2-one; 5-Bromo-1-(diethoxyphosphinyl)-4-hydroxypentan-2-one; Diethyl (5-bromo-4-hydroxy-2-oxopentyl)phosphonate; (5-Bromo-4-hydroxy-2-oxopentyl)phosphonic acid diethyl ester
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-1-Diethoxyphosphinyl-4-Hydroxypentan-2-One is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing, including chromatographic purity analysis and identity confirmation. Certificates of Analysis (COA) detailing batch-specific results are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. Consider storing under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.