Description

(Benzyloxy)Chlorodiazirine is a specialized diazirine-based photoaffinity labeling reagent. This compound is valued for its ability to generate highly reactive carbene intermediates upon photolysis, enabling covalent cross-linking to biological targets for structural and interaction studies. It is primarily utilized by researchers and manufacturers in the fields of chemical biology, pharmaceutical development, and proteomics who require precise tools for mapping biomolecular interactions.

Application

• Photoaffinity Labeling (PAL): A critical reagent for covalent cross-linking studies in chemical biology to investigate protein-ligand, protein-protein, and protein-nucleic acid interactions.
• Proteomics Research: Used to tag and identify binding sites and transient interaction partners of small molecule drugs or bioactive compounds.
• Drug Discovery Platforms: Integral to fragment-based drug discovery (FBDD) and activity-based protein profiling (ABPP) for target identification and validation.
• Bioconjugation Chemistry: Serves as a photochemical handle for the site-specific modification of biomolecules, including antibodies and oligonucleotides.
• Materials Science: Applied in surface functionalization and the creation of cross-linked polymer networks via photochemical curing processes.

Basic Information

Product Name	(Benzyloxy)Chlorodiazirine
CAS No.	113711-60-7
Molecular Formula	C8H7ClN2O
Molecular Weight	182.61 g/mol
Synonyms	3H-Diazirine, 3-chloro-3-(phenylmethoxy)-; 3-Chloro-3-(benzyloxy)diazirine; Benzyloxy(chloro)diazirine; Chloro(benzyloxy)diazirine; Photoaffinity Labeling Reagent PAL; BnO-Cl-Diazirine; Diazirine Photoprobe
EINECS	Contact for details

Quality Control

Our (Benzyloxy)Chlorodiazirine is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and decomposition. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.