Description

4,4,4-Trifluorobut-2-Yn-1-Ol is a high-value fluorinated alkyne building block with a terminal hydroxyl group, enabling versatile chemical transformations. Its unique structure, combining a trifluoromethyl group with an alkyne and an alcohol, makes it a critical intermediate for introducing fluorine motifs into complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to enhance the metabolic stability, lipophilicity, and bioavailability of their target compounds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides where the trifluoromethyl group improves biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent for creating specialty polymers and advanced materials with unique surface properties.
• Ligand and Catalyst Development: Employed in the synthesis of sophisticated fluorinated ligands for catalysis and molecular recognition applications.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of positron emission tomography (PET) imaging tracers, leveraging the alkyne moiety for click chemistry.
• Organic Synthesis Building Block: Utilized in Sonogashira couplings, Huisgen cycloadditions, and other C-C bond-forming reactions to construct complex fluorinated architectures.

Basic Information

Product Name	4,4,4-Trifluorobut-2-Yn-1-Ol
CAS No.	113439-92-2
Molecular Formula	C4H3F3O
Molecular Weight	124.06 g/mol
Synonyms	4,4,4-Trifluoro-2-butyn-1-ol; 4,4,4-Trifluorobut-2-yn-1-ol; 3,3,3-Trifluoroprop-1-yn-1-ylmethanol; 4,4,4-Trifluorobutynol; 2-Butyn-1-ol, 4,4,4-trifluoro-; 4,4,4-Trifluoro-2-butynol; 4,4,4-Trifluoro-2-butyn-1-ol (stabilized with TBC)
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorobut-2-Yn-1-Ol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) for each lot, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to the presence of the alkyne and alcohol functional groups, it is recommended to store under an inert atmosphere for long-term stability and to minimize the risk of polymerization or oxidation. Keep away from strong oxidizers, acids, and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.