Description

2,3-Difluorobenzyl Bromide is a versatile and high-value fluorinated benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in introducing both the difluorobenzyl and reactive bromomethyl functional groups into target molecules, enabling the development of compounds with enhanced biological activity and physicochemical properties. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, particularly for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting the central nervous system, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in developing advanced herbicides, fungicides, and insecticides where the difluorobenzyl moiety can improve metabolic stability and binding affinity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials, leveraging fluorine's properties to modify polarity and stability.
• Cross-Coupling Reactions: Acts as an electrophile in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct complex biaryl structures.
• Ligand & Catalyst Development: Employed in the preparation of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Fluorine-18 Labeling Precursor: Potential use as a precursor in radiochemistry for Positron Emission Tomography (PET) tracer development.

Basic Information

Product Name	2,3-Difluorobenzyl Bromide
CAS No.	113211-94-2
Molecular Formula	C7H5BrF2
Molecular Weight	207.02 g/mol
Synonyms	1-(Bromomethyl)-2,3-difluorobenzene; (2,3-Difluorophenyl)methyl Bromide; α-Bromo-2,3-difluorotoluene; 2,3-Difluorobenzylbromide; 2,3-DFBB; 2,3-Difluoro-α-bromotoluene; 2,3-Difluorobenzyl Bromide
EINECS	Contact for details

Quality Control

Our 2,3-Difluorobenzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We employ advanced analytical techniques including GC, HPLC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality management system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids, bases, and oxidizing agents. Due to its sensitivity to light and moisture, containers should be kept sealed under an inert atmosphere when not in use for extended periods.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Assay (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.