Description

3-(3-Trifluoromethyl-Phenyl)-Acrylic Acid Ethyl Ester is a versatile fluorinated acrylate ester building block, prized for its unique trifluoromethylphenyl moiety which imparts enhanced lipophilicity and metabolic stability to target molecules. This compound is a critical intermediate in the synthesis of advanced pharmaceutical agents and high-performance specialty chemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated monomers used in electronic display technologies and organic light-emitting diodes (OLEDs).
• Polymer Modification: Acts as a functional monomer to introduce fluorinated aromatic groups into polymers, improving chemical resistance and surface properties.
• Chemical Research & Development: A valuable reagent in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Specialty Fine Chemicals: Intermediate for producing dyes, pigments, and other performance chemicals requiring specific fluorinated aromatic structures.

Basic Information

Product Name	3-(3-Trifluoromethyl-Phenyl)-Acrylic Acid Ethyl Ester
CAS No.	113048-68-3
Molecular Formula	C₁₂H₁₁F₃O₂
Molecular Weight	244.21 g/mol
Synonyms	Ethyl 3-[3-(Trifluoromethyl)phenyl]acrylate; Ethyl 3-(3-Trifluoromethylphenyl)propenoate; 3-(3-Trifluoromethylphenyl)acrylic Acid Ethyl Ester; (E)-Ethyl 3-(3-(trifluoromethyl)phenyl)acrylate; α,β-Unsaturated Ester with Trifluoromethylphenyl Group; m-Trifluoromethylcinnamic Acid Ethyl Ester; TFM-Cinnamate Ethyl Ester
EINECS	Contact for details

Quality Control

Our production of 3-(3-Trifluoromethyl-Phenyl)-Acrylic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, GC for residual solvents, and NMR/IR for structural confirmation, to ensure consistency and reliability. Certificates of Analysis (COA) documenting all critical specifications are available upon request, supporting your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.