Description

1-(4-Amino-2-Fluorophenyl)Ethanone is a high-purity fluorinated aromatic ketone intermediate of significant importance in advanced organic synthesis. Its molecular structure, featuring both an amino and a fluorine substituent on the aromatic ring, makes it a versatile and valuable building block for constructing complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of new active ingredients. We supply this critical intermediate with a focus on consistent quality and reliable global supply chain support.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-inflammatory agents, and oncology treatments.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atom enhances biological activity, stability, and selectivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and catalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers, liquid crystals, and organic electronic materials that require fluorinated aromatic components.
• Chemical Research & Development: A valuable scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.

Basic Information

Product Name	1-(4-Amino-2-Fluorophenyl)Ethanone
CAS No.	112279-56-8
Molecular Formula	C8H8FNO
Molecular Weight	153.15 g/mol
Synonyms	2'-Fluoro-4'-aminoacetophenone; 4-Amino-2-fluoroacetophenone; 1-Acetyl-4-amino-2-fluorobenzene; 2-Fluoro-4-aminoacetophenone; 4-Acetylamino-3-fluorobenzene (tautomer); 4'-Amino-2'-fluoroacetophenone; 2-Fluoro-4-acetamidobenzene; Ethanone, 1-(4-amino-2-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our production of 1-(4-Amino-2-Fluorophenyl)Ethanone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment. We support customer audits and can tailor specifications to meet the requirements of cGMP, ICH Q7, or other relevant regulatory frameworks for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	Light yellow to beige crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.