Description

(S)-Modafinil CAS NO 112111-47-4 is the S-enantiomer of the well-known wakefulness-promoting agent, Modafinil. This high-purity chiral compound is critical for advanced pharmaceutical research and development, particularly in the study of stereoselective pharmacological effects. It is primarily utilized by pharmaceutical manufacturers, research institutions, and contract development organizations focused on central nervous system (CNS) therapeutics, enantiomer-specific drug development, and analytical reference standards.

Application

• Pharmaceutical Reference Standard: Serves as a critical chiral reference material for analytical method development, validation, and quality control (QC) in pharmaceutical manufacturing.
• Enantioselective Pharmacological Research: Used in preclinical and clinical research to isolate and study the specific biological activity, metabolism, and pharmacokinetics of the S-enantiomer.
• Active Pharmaceutical Ingredient (API) Intermediate: Employed in the synthesis and development of novel, enantiomerically pure pharmaceutical compounds targeting sleep disorders and CNS conditions.
• Academic & Institutional Research: A key reagent in university and institutional labs for neuroscience, medicinal chemistry, and behavioral pharmacology studies.
• Bioanalytical Assay Development: Essential for creating and calibrating assays (e.g., HPLC, LC-MS) to quantify Modafinil enantiomers in biological matrices.
• Regulatory Submissions: Provides the necessary high-purity material for stability studies, impurity profiling, and documentation required for regulatory filings (e.g., FDA, EMA).

Basic Information

Product Name	(S)-Modafinil
CAS No.	112111-47-4
Molecular Formula	C15H15NO2S
Molecular Weight	273.35 g/mol
Synonyms	(S)-2-[(Diphenylmethyl)sulfinyl]acetamide; (S)-Modafinil; (-)-Modafinil; S-Modafinil; CRL-40967; (S)-Diphenylmethylsulfinylacetamide; (S)-Benzhydrylsulfinylacetamide; Armodafinil Related Compound S (USP)
EINECS	Contact for details

Quality Control

Our (S)-Modafinil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and chiral excess. Our quality commitment aligns with the expectations of cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.