Description

(R)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole CAS NO 112022-83-0 is a highly specialized chiral oxazaborolidine catalyst, a cornerstone in modern asymmetric synthesis. Its value lies in enabling highly enantioselective transformations, critical for producing single-isomer pharmaceutical intermediates and fine chemicals with precise stereochemistry. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-performance catalysts for scalable, stereocontrolled reactions.

Application

• Asymmetric Reduction Catalyst: Employed as a chiral catalyst for the enantioselective reduction of prochiral ketones to secondary alcohols, a fundamental step in API synthesis.
• Pharmaceutical Intermediate Synthesis: Critical for constructing chiral centers in active pharmaceutical ingredients (APIs) for CNS drugs, antivirals, and other therapeutics.
• Agrochemical Manufacturing: Used in the production of enantiomerically pure herbicides, fungicides, and pesticides for enhanced efficacy and environmental safety.
• Fine Chemical and Fragrance Production: Facilitates the synthesis of chiral flavor and fragrance compounds with high olfactory specificity.
• Academic and Industrial R&D: A vital tool in methodological development for new asymmetric reactions and process optimization in laboratory and pilot-scale settings.
• Material Science: Potential application in the synthesis of chiral polymers and liquid crystals with specific optical properties.

Basic Information

Product Name	(R)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole
CAS No.	112022-83-0
Molecular Formula	C19H20BNO
Molecular Weight	289.18 g/mol
Synonyms	(R)-3,3-Diphenyl-1-methyl-1,3,2-oxazaborolidine; (R)-Diphenylprolinol Methylborate; (R)-1-Methyl-3,3-diphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (R)-Methyl Diphenylprolinol Boronate; Corey's (R)-Oxazaborolidine Catalyst; (R)-CBS Catalyst; (R)-2-Methyl-CBS-oxazaborolidine; (R)-Me-CBS
EINECS	Contact for details

Quality Control

Every batch of our (R)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high standards required for catalytic applications, including chiral purity (enantiomeric excess) and chemical purity. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting key parameters such as assay, identity, and impurity profile.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition and maintain catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.