Description

(S)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole is a high-purity, chiral oxazaborolidine catalyst essential for achieving exceptional enantioselectivity in organic synthesis. Its value lies in enabling the production of single-enantiomer intermediates and active pharmaceutical ingredients (APIs) with high yield and purity. This compound is a critical reagent for research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries requiring precise asymmetric transformations.

Application

• Asymmetric Catalysis: As a chiral Lewis acid catalyst for enantioselective Diels-Alder, aldol, and reduction reactions.
• Pharmaceutical Intermediate Synthesis: Key for constructing chiral centers in the development of novel APIs and drug candidates.
• Agrochemical Production: Used in the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Fine Chemical Manufacturing: Enables the production of high-value chiral flavors, fragrances, and specialty materials.
• Academic & Process R&D: A vital tool for methodological development and scaling up asymmetric synthetic routes in laboratory settings.
• Material Science: Potential applications in the synthesis of chiral polymers and advanced organic materials.

Basic Information

Product Name	(S)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole
CAS No.	112022-81-8
Molecular Formula	C19H20BNO
Molecular Weight	289.18 g/mol
Synonyms	(S)-1-Methyl-3,3-diphenyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (S)-3,3-Diphenyl-1-methyltetrahydro-1H,3H-pyrrolo[1,2-c][1,3,2]oxazaborole; (S)-Diphenylprolinol Methylborane; (S)-Diphenylprolinol Borane Complex; Corey's (S)-Diphenylprolinol Catalyst; (S)-α,α-Diphenyl-2-pyrrolidinemethanol Methylborane; (S)-1-Methyl-3,3-diphenyl-2-aza-3-borabicyclo[3.3.0]octane
EINECS	Contact for details

Quality Control

Every batch of our (S)-3,3-Diphenyl-1-Methylpyrrolidino[1,2-C]-1,3,2-Oxazaborole is manufactured and tested under strict quality management systems to ensure consistent high purity and chiral integrity, suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, enantiomeric excess (ee), and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical-grade chiral auxiliaries and catalysts.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (ee)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.