Description

2-(2,4,6-Trifluorophenyl)Acetaldehyde is a high-value fluorinated aromatic aldehyde building block, essential for introducing the 2,4,6-trifluorophenyl moiety into complex molecular architectures. Its primary commercial value lies in its role as a versatile intermediate in the synthesis of advanced pharmaceuticals and agrochemicals, where the fluorine atoms enhance metabolic stability, bioavailability, and binding affinity. This compound is particularly critical for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for drugs targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, fungicides, and insecticides, where the trifluoromethylphenyl group improves lipophilicity and environmental stability.
• Liquid Crystal Materials: Used in the production of fluorinated compounds for electronic displays, leveraging its aromatic and fluorine properties to modify dielectric anisotropy.
• Organic Synthesis & Catalysis: Serves as a substrate in cross-coupling reactions, Grignard reactions, and reductive amination for creating complex organic molecules in academic and industrial research.
• Material Science: Intermediate for synthesizing specialty polymers and advanced materials requiring fluorinated aromatic units for enhanced thermal and chemical resistance.

Basic Information

Product Name	2-(2,4,6-Trifluorophenyl)Acetaldehyde
CAS No.	111991-19-6
Molecular Formula	C8H5F3O
Molecular Weight	174.12 g/mol
Synonyms	2,4,6-Trifluorophenylacetaldehyde; (2,4,6-Trifluorophenyl)Acetaldehyde; 2-(2,4,6-Trifluorophenyl)Ethanal; α,2,4,6-Tetrafluorotoluene (obsolete); 1-(2,4,6-Trifluorophenyl)-2-oxoethane; TFPA; 2,4,6-Trifluoro-benzeneacetaldehyde
EINECS	Contact for details

Quality Control

Every batch of 2-(2,4,6-Trifluorophenyl)Acetaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.