Description

(E)-2-Fluoro-3-(4-Fluorophenyl)-Propenoic Acid, Ethyl Ester is a high-purity fluorinated organic building block of significant interest in advanced chemical synthesis. This compound matters for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and agrochemicals, where its specific stereochemistry and fluorine atoms are critical for bioactivity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce fluorinated motifs into complex molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine substitution enhances metabolic stability and biological activity.
• Liquid Crystal & OLED Material Precursor: Serves as a specialized intermediate in the manufacture of fluorinated organic compounds for electronic displays and optoelectronic devices.
• Chemical Research & Development: Employed in academic and industrial labs for method development, catalysis studies, and exploring new fluorination reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific fluorinated target molecules.

Basic Information

Product Name	(E)-2-Fluoro-3-(4-Fluorophenyl)-Propenoic Acid, Ethyl Ester
CAS No.	111055-87-9
Molecular Formula	C11H10F2O2
Molecular Weight	212.19 g/mol
Synonyms	Ethyl (E)-2-Fluoro-3-(4-fluorophenyl)acrylate; (E)-Ethyl 2-Fluoro-3-(4-fluorophenyl)propenoate; 2-Fluoro-3-(4-fluorophenyl)acrylic Acid Ethyl Ester; trans-2-Fluoro-3-(4-fluorophenyl)acrylic Acid Ethyl Ester; 4-Fluorocinnamic Acid, 2-Fluoro-, Ethyl Ester; Ethyl (E)-α-Fluoro-β-(4-fluorophenyl)acrylate; Propenoic acid, 2-fluoro-3-(4-fluorophenyl)-, ethyl ester, (E)-
EINECS	Contact for details

Quality Control

Our (E)-2-Fluoro-3-(4-Fluorophenyl)-Propenoic Acid, Ethyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.