Description

2-(4-Fluoro-Phenyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid is a high-purity, functionalized isoindole-1,3-dione derivative, also known as a phthalimide analog, serving as a critical advanced pharmaceutical intermediate (API) and a versatile building block in organic synthesis. Its value lies in the precise fluorinated aromatic and carboxylic acid functionalities, which are essential for modulating the biological activity, solubility, and metabolic stability of target molecules. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology, neurology, and anti-inflammatory research.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and plant growth regulators leveraging its fluorinated aromatic core.
• Organic Light-Emitting Diodes (OLEDs): Acts as a precursor for electron-transport materials or host materials in OLED device fabrication.
• Polymer Chemistry: Serves as a monomer or functionalization agent for creating specialty polymers with enhanced thermal or chemical resistance.
• Material Science Research: Utilized in the development of advanced organic semiconductors and non-linear optical (NLO) materials.
• Bioconjugation & Probe Development: The carboxylic acid group enables coupling to biomolecules (peptides, proteins) for creating diagnostic probes or targeted conjugates.

Basic Information

Product Name	2-(4-Fluoro-Phenyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid
CAS No.	110768-19-9
Molecular Formula	C15H8FNO4
Molecular Weight	285.23 g/mol
Synonyms	5-Carboxy-2-(4-fluorophenyl)isoindole-1,3-dione; 4-Fluoro-N-(5-carboxy-1,3-dioxoisoindolin-2-yl)benzamide (tautomer); 2-(p-Fluorophenyl)-1,3-dioxoisoindoline-5-carboxylic acid; 5-Carboxy-2-(4-fluorophenyl)phthalimide; 1H-Isoindole-5-carboxylic acid, 2,3-dihydro-2-(4-fluorophenyl)-1,3-dioxo-; Fluorophenylphthalimide carboxylic acid; API Intermediate 110768-19-9
EINECS	Contact for details

Quality Control

Our production of 2-(4-Fluoro-Phenyl)-1,3-Dioxo-2,3-Dihydro-1H-Isoindole-5-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity suitable for research and GMP manufacturing. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.