Description

5-(Chloromethyl)-3-(2-Fluorophenyl)-1,2,4-Oxadiazole is a high-value heterocyclic building block, specifically a functionalized 1,2,4-oxadiazole derivative. This compound matters for its role as a versatile synthetic intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. Pharmaceutical and agrochemical R&D teams need it to construct complex molecules, leveraging its reactive chloromethyl and fluorophenyl groups for further chemical elaboration.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where the 1,2,4-oxadiazole core is a privileged scaffold.
• Chemical Biology & Proteomics: Serves as a reactive handle in the creation of chemical probes and affinity tags for studying protein function and interactions.
• Material Science Research: Investigated as a monomer or cross-linking agent for the development of advanced polymers with specific thermal or optical properties.
• Academic & Contract Research: Employed in university and CRO laboratories for method development and exploration of novel heterocyclic chemistry.

Basic Information

Product Name	5-(Chloromethyl)-3-(2-Fluorophenyl)-1,2,4-Oxadiazole
CAS No.	110704-45-5
Molecular Formula	C9H6ClFN2O
Molecular Weight	212.61 g/mol
Synonyms	3-(2-Fluorophenyl)-5-(chloromethyl)-1,2,4-oxadiazole; 1,2,4-Oxadiazole, 5-(chloromethyl)-3-(2-fluorophenyl)-; 5-(Chloromethyl)-3-(o-fluorophenyl)-1,2,4-oxadiazole; 2-Fluorophenyl-5-chloromethyl-1,2,4-oxadiazole; Oxadiazole chloromethyl fluorophenyl derivative
EINECS	Contact for details

Quality Control

Our 5-(Chloromethyl)-3-(2-Fluorophenyl)-1,2,4-Oxadiazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent identity. Certificates of Analysis (COA) with full traceability are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.