Description

L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (2-α-,4-α-,5-α-)- (9Ci) CAS NO 110658-38-3 is a specialized, non-proteinogenic amino acid derivative with a complex stereochemistry, offering unique structural and functional properties for advanced chemical synthesis. This compound is valued for its role as a high-purity chiral building block and intermediate in the development of novel bioactive molecules. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications in drug discovery, peptide modification, and catalyst design.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, particularly protease inhibitors and other targeted therapeutics.
• Peptide Chemistry & Research: Used to introduce constrained, hydroxylated proline analogs into peptide chains to study structure-activity relationships and enhance metabolic stability.
• Agrochemical Development: Serves as a precursor in creating novel, biologically active compounds for crop protection products.
• Catalyst & Ligand Synthesis: Employed in the design of chiral catalysts and ligands for asymmetric synthesis applications.
• Biochemical Research: Utilized as a standard or probe in enzymatic studies and metabolic pathway analysis.
• Fine Chemical Production: Acts as a specialized intermediate for custom synthesis and the manufacture of high-value chemical products.

Basic Information

Product Name	L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (2-α-,4-α-,5-α-)- (9Ci)
CAS No.	110658-38-3
Molecular Formula	C7H13NO4
Molecular Weight	175.18 g/mol
Synonyms	(2S,4S,5S)-4-Hydroxy-5-(hydroxymethyl)proline; 4-Hydroxy-5-(hydroxymethyl)-L-proline; (2α,4α,5α)-4-Hydroxy-5-(hydroxymethyl)proline; L-4-Hydroxy-5-(hydroxymethyl)proline; Hydroxymethylhydroxyproline; A derivative of 4-Hydroxyproline; Contact for additional trade names.
EINECS	Contact for details

Quality Control

Our production of L-Proline, 4-Hydroxy-5-(Hydroxymethyl)-, (2-α-,4-α-,5-α-)- (9Ci) adheres to stringent quality management protocols. Each batch is subjected to comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets exacting research and production standards. Certificates of Analysis (COA) detailing identity, purity, and specific tests are provided with every shipment to guarantee traceability and consistency for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent product degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.