Description

L-Proline, 5-(1-Methylethyl)-, trans- (9Ci) CAS NO 110452-58-9 is a specialized, non-proteinogenic proline derivative characterized by an isopropyl substitution at the 5-position of the pyrrolidine ring. This structural modification makes it a valuable chiral building block and intermediate in advanced organic synthesis, particularly for the development of novel pharmaceuticals and bioactive compounds. It is primarily sought after by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for applications in asymmetric synthesis, peptide mimetics, and medicinal chemistry research.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), especially in protease inhibitor and peptidomimetic drug candidates.
• Asymmetric Synthesis: Serves as a versatile precursor or catalyst ligand in stereoselective reactions to construct complex molecules with high enantiomeric purity.
• Peptide Chemistry: Used to introduce conformational constraints or novel side chains into synthetic peptides to modulate their biological activity, stability, and receptor binding properties.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or plant growth regulators that require specific chiral architectures.
• Biochemical Research: Utilized as a substrate analog or inhibitor in enzymatic studies to probe the function of proline-specific enzymes.
• Fine Chemical Synthesis: Acts as a building block for specialty chemicals, flavors, fragrances, and advanced materials requiring high-purity chiral components.

Basic Information

Product Name	L-Proline, 5-(1-Methylethyl)-, trans- (9Ci)
CAS No.	110452-58-9
Molecular Formula	C8H15NO2
Molecular Weight	157.21 g/mol
Synonyms	(2S,5S)-5-Isopropylproline; trans-5-Isopropyl-L-proline; (2S,5S)-5-(1-Methylethyl)-2-pyrrolidinecarboxylic acid; L-5-Isopropylproline; (2S,5S)-5-(Propan-2-yl)proline; 5-Isopropyl-L-proline; (S,S)-5-Isopropylproline
EINECS	Contact for details

Quality Control

Our production of L-Proline, 5-(1-Methylethyl)-, trans- (9Ci) adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurity profiles are provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (de)
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.